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	Provedor de dados BJID (1) BJMBR (1) Autor Brandão,Lucas A.C. (1) Coelho,Antonio V.C. (1) Crovella,Sergio (1) Donadi,E.A. (1) Ferraz,A.S. (1) Guimarães,Rafael L. (1) Kimachi,T. (1) Moura,Ronald R. de (1) Paula-Santos,C.M. (1) Voltarelli,J.C. (1) Mais... Palavra-chave Immunogenetics (2) Alport's syndrome (1) Genetic association study (1) HIV-1 (1) HLA antigens (1) MHC (1) Pharmacodynamics (1) Survival analysis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 1998 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Antiretroviral therapy immunologic non-response in a Brazilian population: association study using pharmaco- and immunogenetic markers BJID Coelho,Antonio V.C.; Moura,Ronald R. de; Guimarães,Rafael L.; Brandão,Lucas A.C.; Crovella,Sergio. ABSTRACT Background: Antiretroviral therapy (ART) saved millions from HIV-1 infection and AIDS, but some patients do not experience adequate CD4+ T cells gain despite achieving viral suppression. The genetic component of this condition is not yet completely elucidated. Objective: To identify predictive genetic markers of immune response to ART. Methods: Case–control study. Out of 176 HIV-infected patients recruited in the city of Recife, Northeast Brazil, 67 patients with no immunologic response were the cases and the remaining 109 patients who responded were the controls. A set of 94 selected single nucleotide polymorphisms (SNPs) involved in antiretroviral drugs pharmacodynamic pathways and immune system homeostasis were genotyped, while the remaining... Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV-1; Pharmacodynamics; Immunogenetics; Genetic association study; Survival analysis. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500392 Association of Alport's syndrome with HLA-DR2 antigen in a group of unrelated patients BJMBR Donadi,E.A.; Voltarelli,J.C.; Paula-Santos,C.M.; Kimachi,T.; Ferraz,A.S.. A few family studies have evaluated HLA antigens in Alport's syndrome; however, there are no large population studies. In the present report, we studied 40 unrelated white patients with Alport's syndrome seen at the Unit of Renal Transplantation, Faculty of Medicine of Ribeirão Preto, São Paulo, Brazil. HLA-A, -B, -DR and -DQ antigens were typed using a complement-dependent microlymphocytotoxicity assay. A control white population (N = 403) from the same geographical area was also typed for HLA antigens. Although the frequencies of HLA-A and -B antigens of patients were not statistically different from controls, the frequency of HLA-DR2 antigen observed in patients (65%) was significantly increased in relation to controls (26%; P<0.001). The... Tipo: Info:eu-repo/semantics/article Palavras-chave: HLA antigens; Alport's syndrome; MHC; Immunogenetics. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400010 Registros recuperados: 2 Primeira ... 1 ... Última

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